7 Fat-Burning Hormones and How They Work

You're likely familiar with the consequences of a terrible night's sleep. You're cranky, feeling awful, and coasting on mammoth cups of coffee along with some high-sugar impact dessert masquerading as breakfast. "It's going to be one of those days," you reluctantly say late morning, assuaging your frustration with your coworker's homemade brownies.

That miserable, out-of-whack feeling isn't just in your head. When you don't sleep well,  numerous fat-regulating hormones become imbalanced, sending you on a downward spiral of hunger, cravings, blowing off your workout, and crashing on the couch after a brutal day at the office to nose dive into deep dish while watching Friends reruns.

Let's check out seven hormones that easily get knocked off balance, sometimes with just one night's terrible sleep:

  1. Leptin. This hormone tells your brain to put the brakes on food and stop eating. You want optimal leptin levels, but you also want your brain to get this hormone's signal. Leptin resistance occurs when your body makes this hormone but your brain can't "hear" it, leading you to overeat. One study published in The Journal of Clinical Endocrinology and Metabolism found sleep levels influence leptin levels. Researchers discovered when leptin gets out of balance, so do other hormones like cortisol and thyroid-stimulating hormone (TSH). 
  2. Ghrelin. Leptin's polar opposite sister, ghrelin tells your brain to eat now. Increased amounts mean you're more likely to make that 11 p.m. butter pecan freezer raid. One study published in the Journal of Sleep Research found even one night of poor sleep increased ghrelin levels and hunger in healthy normal-weight men, paving the path for weight loss resistance.
  3. Adiponectin. This anti-inflammatory hormone helps predict heart disease risk and regulates metabolic processes like fat breakdown. Studies find optimized adiponectin reduces your risk for insulin resistance and Type 2 diabetes. One study published in the journal Physiology and Behavior concluded reduced sleep decreases adiponectin production, increasing cardiovascular risk in Caucasian women.
  4. Insulin. Insulin becomes a key example of "everything in balance." Cranked-up amounts of this hormone store rather than burn fat and slam your fat-cell doors shut. One study published in The Journal of Applied Physiology found chronic sleep loss decreased insulin sensitivity, increased hunger and appetite, and contributes to weight gain, insulin resistance and diabetes.
  5. Glucagon. This hormone releases fat to burn for energy (the opposite of insulin), so yes, glucagon is our bestie for fast, lasting fat loss. One study published in The Journal of Clinical Endocrinology and Metabolism found 10 men who only got 4.5 hours of sleep had lower circulating levels of glucagon.
  6. Cortisol. This stress hormone benefits you in the short term, but it should do its job and then chill out. Chronically elevated cortisol levels store fat and break down muscle. Cortisol levels should be highest in the morning and taper throughout the day. One study published in the journal Sleep found inadequate sleep could increase stress, increase appetite and lead to metabolic and cognitive problems, setting the stage for further sleep deprivation.
  7. Growth hormone. Sometimes referred to as your "fountain of youth" hormone that helps build muscle, boost energy, and improve fat metabolism, you primarily make growth hormone (GH) during deep stage 4 sleep. You won't be surprised, then, to learn light sleepers and people who wake up often during the night might not be making optimal amounts. Indeed, one study published in the Journal of Psychiatry and Neuroscience showed inadequate sleep means your body makes less GH.

Optimized sleep becomes my number one strategy for fast, lasting fat loss and optimal health. Prioritize it, power down an hour before bedtime, and create a ritual that helps you drift into deep, replenishing sleep. 

What's the biggest obstacle you confront after a terrible night's sleep? Mine is overdoing caffeine the next day.  Share your experiences below in Comments, they might help others.

Davidson JR, et al. Growth hormone and cortisol secretion in relation to sleep and wakefulness. J Psychiatry Neurosci. 1991 July; 16(2): 96-102.

Greer SM, et al. The impact of sleep deprivation on food desire in the human brain. Nat Commun. 2013 Aug 6;4:2259. doi: 10.1038/ncomms3259.

Leproult R, et al. Sleep loss results in an elevation of cortisol levels the next evening. Sleep. 1997 Oct;20(10):865-70.

Schmid SM, et al. A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. J Sleep Res. 2008 Sep;17(3):331-4. doi: 10.1111/j.1365-2869.2008.00662.x. Epub 2008 Jun 28.

Schmid SM, et al. Mild sleep restriction acutely reduces plasma glucagon levels in healthy men. J Clin Endocrinol Metab. 2009 Dec;94(12):5169-73. doi: 10.1210/jc.2009-0969. Epub 2009 Oct 16.
Simpson NS, et al. Effects of sleep restriction on adiponectin levels in healthy men and women. Physiol Behav. 2010 Dec 2;101(5):693-8. doi: 10.1016/j.physbeh.2010.08.006. Epub 2010 Aug 17.
Spiegel K, et al. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol. 2005 Nov;99(5):2008-19.

Spiegel K, et al. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab. 2004 Nov;89(11):5762-71.

10/11/2021 8:00:00 AM
JJ Virgin
Written by JJ Virgin
Celebrity Nutrition & Fitness Expert JJ Virgin helps clients lose weight fast by breaking free from food intolerances and crushing their sugar cravings. She is author of New York Times Bestsellers The Virgin Diet: Drop 7 Foods, Lose 7 Pounds, Just 7 Days, The Virgin Diet Cookbook: 150 Easy and Delicious Recipes to Lose W...
View Full Profile Website: http://www.jjvirgin.com/

Hey, so, when my fiance doesn't sleep well, which is often, unfortunately, he either winds up on the sofa or sleeps most of the day the next day, & he's got chronic pain issues, which we're dealing with
Posted by Michelle Homewood
Where is the promised "what you can do to get your hormones working optimally again?" Is getting more sleep all you can do?
Posted by nikavt
Wellness.com does not provide medical advice, diagnosis or treatment nor do we verify or endorse any specific business or professional listed on the site. Wellness.com does not verify the accuracy or efficacy of user generated content, reviews, ratings or any published content on the site. Use of this website constitutes acceptance of the Terms of Use.
©2024 Wellness®.com is a registered trademark of Wellness.com, Inc. Powered by Earnware