Gallery Peptides On The Cell Surface

In defense against viruses and other parasites in the cell are important T-cells. Recognize infected cells by MHC proteins. They exhibit at the surface of nearly all cells of the body samples of fragments of proteins synthesized by the cell. It's a sort of gallery of thousands MHC protein complexes ( Figure ). A T-lymphocytes are specialized just for identification of these complexes. Use the surface of T-receptors which are structurally related antibodies. If the cell is healthy, has normal surface proteins of MHC complexes with peptides, and therefore ignore Lymphocyte cell (those which would not ignore it, have already be destroyed in the thymus). However, if the cell is detected (eg, a virus), appear on the surface CHM-protein complexes with viral peptides. You do specific T-cells perceive as foreign. The immune system of infected cells thus treated, but straight kills them. It even sometimes happens that T-cells attack infected tissue damage more than it would harm the virus itself.



In a population of MHC proteins exist in many forms, which differ only by what peptide fragments bind. Make it impossible for the virus to escape the immune system so that it would no peptide fragments of the proteins to the MHC proteins undeveloped.acne no more review On the other hand, it is precisely the diversity of MHC proteins cause problems in organ transplantation. The spectrum of normal MHC complexes of proteins and peptide fragments are genetically distinct individuals with different. When transplanted kidney, T-lymphocytes genetically different transplant recipient appears infected and tries to destroy it. This undesired activity of the recipient's immune system suppresses defense response suppressing drugs (immunosuppressive).



To T-cells have evolved defense response against infected cells, the naive T-cells (those that have not yet encountered antigen) first recognize MHC complex proteins with viral peptide on the surface of specialized cells exhibiting in his "gallery" antigen 1) and only after contact with these cells, the T-lymphocyte wakes from sleep naive and begins to divide and differentiate ( Figure ). Best exhibitor’s antigen dendrite cells are contained in most tissues and lymph nodes.

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