Tree tobacco (Nicotiana glauca) comes from Argentina, Paraguay, and Bolivia and is now a common plant in California. Tree tobacco should not be confused with smoking tobacco (Nicotiana tabacum). It is on the list of toxic plants in several states, including Texas, California, and North Carolina. Native Americans in some areas substitute it for native tobacco. To enhance the spiritual experience, tree tobacco is sometimes smoked by California Native Americans in combination with Datura wrightii, which may be dangerous as both plants induce respiratory depression.
Tree tobacco has been publicized as a safe, hallucinogenic plant on some internet websites. However, smoking or ingesting the plant has lead to death.
There is insufficient evidence in humans to support the use of tree tobacco for any indication.
Akkue musa, anabasine, Brazilian tree tobacco, buena moza, California tree tobacco, cestrum, chlorinated amides, coneton, corneton, cotinine, coyote tobacco, don juan, gandul, gigante, glycosylated cyclohexenone derivatives, isil pivat, jantwak, le tabaque glauque, mahasatpurush, maria-juana, masseyss, Mexican tobacco, mustard tree, myosmine, Nicotiana arborea, nicotine, nornicotine, palau pazau, punche, quercitin, (R)-anabasine, rape, rutin, (S)-anabasine, San Juan tree, satpurush, scopoletin, scopolin, Solanaceae (family), taba, tabaco Cimarron, tabaco moro, tobacco plant, tree tobacco, triacontanol, vitamin D3, wildetabak, wild tobacco, wild tree tobacco, yellow tree tobacco.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.