Tocotrienols

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Vitamin E is an essential fat-soluble nutrient that belongs to the family of tocotrienols and tocopherols. Tocotrienols are found in high concentrations in cereal grains (e.g., oat, barley, rye, and rice bran). The highest level found in crude palm oil. Commercial tocotrienols are primarily obtained from natural sources, such as palm or rice bran oil.
The best food sources of vitamin E are vegetable oils (sunflower and olive), nuts, seeds, and fortified cereals. Tocotrienol supplements are available in capsule and tablet form.
Among vitamin E compounds, tocotrienols are best known for their antioxidant, heart-protective, and anticancer effects. Tocotrienols may also have cholesterol-lowering effects. Research suggests that it is common for cancer patients to combine vitamin E (mixed tocopherols and tocotrienols) and chemotherapy.

Related Terms

6-Hydroxy-2-methyl-2-phytylchroman, 6-O-carboxypropyl-alpha-tocotrienol (T3E), A-84, A HMG-CoA reductase inhibitor, alpha-T3, alpha-T3 H, alpha-tocopherol, alpha-tocopheryl, alpha-tocotrienol, alpha-tocotrienol alpha-plus gamma-complex tocotrienol, beta tocotrienol, beta-tocotrienol, carboxychromanols, carotenoids, delta tocotrienol, delta-tocotrienol, eta-tocopherols, farnesylated benzopyran, gamma tocotrienol, gamma-carotenes, gamma-oryzanol, gamma-tocopheryl, gamma-tocotrienol, gamma-tocotrienyl 2-phenylselenyl succinates, herpigon, high gamma-complex tocotrienol isoprenoid, P25-complex, palm oil, palm olein, palmolein, PalmVitee® tocotrienol, phytonutrients, phytosterols, RBO, TCT, tocochromanols, tocopherols, tocotrienol-rich fraction (TRF), tocotrienol-rich fraction (TRF25), tocotrienols, tocotrienols (PalmVitee®), tocotrienyl acetate supplements, TRF, TRF25, triterpene alcohols, vismione B, vitamin E, vitamin E acetate, vitamin E succinate, vitamin E tocotrienol (TCT), xanthones, zeta.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
Antioxidant (Grade: C)
Tocotrienols have been studied for their antioxidant properties. However, few clinical trials have been conducted. Based on limited research, PalmVitee®, a tocotrienol- and tocopherol-enriched fraction of palm oil, demonstrated antioxidant properties in patients with cerebrovascular disease. Additional high-quality clinical studies are needed before a firm conclusion can be drawn.
Cardiac abnormalities (autonomic/hypertensive crises and cardiac instability associated with familial dysautonomia) (Grade: C)
Familial dysautonomia (FD) is an inherited, fatal neurodegenerative disorder with symptoms of severe increases in blood pressure and cardiac instability. Patients with this condition make insufficient amounts of at least two proteins. Ingestion of tocotrienols can raise the levels of these proteins in these patients. Additional high-quality clinical studies are needed before a firm conclusion can be drawn.
Diabetes (Grade: C)
According to limited research, intake of tocotrienols may result in a decreased risk of type 2 diabetes. Additional high-quality clinical studies are needed before a firm conclusion can be drawn.
High cholesterol (Grade: C)
There is mixed clinical evidence on the role of tocotrienols in reducing cholesterol levels. Additional high-quality clinical studies are needed before a firm conclusion can be drawn.