Pyruvate

background

Pyruvate is a three-carbon organic acid (alpha-ketocarboxylic acid) that is formed in the body during glycolysis, a metabolic process that converts glucose to pyruvate.
Pyruvate supplementation is commonly used for weight and fat loss. In general, the marketing of pyruvate for these purposes is based on studies using a combination of pyruvate and dihydroxyacetone. While several clinical trials do support the use of pyruvate for this purpose, results are mixed overall. Although pyruvate is commonly used for exercise performance improvement, this use is not supported by scientific evidence.
There is inconclusive evidence regarding the use of pyruvate for alcoholic liver disease, chronic obstructive pulmonary disease (COPD), congestive heart failure, high cholesterol, and hyperkeratotic skin conditions. Further research is also needed to assess the effects of pyruvate in combination with cardioplegic solution for protecting heart muscle during surgery.

Related Terms

2-Chloroethylpyruvate, 2-oxopropanoate, 2-oxypropanoic acid, acetylformate, acetylformic acid, alpha-keto acid, alpha-ketocarboxylic acid, alpha-ketopropionate, alpha-ketopropionic acid, calcium pyruvate, calcium pyruvate monohydrate, creatine pyruvate, Diet Pyruvate™, ethyl pyruvate, magnesium pyruvate, methyl pyruvate, o-ethoxybenzylhydrazone of diethanolamine pyruvate, organic acid, potassium pyruvate, proacemic acid, pyr, pyroracemate, pyroracemic acid, Pyruvate™ 1000, pyruvate anion, Pyruvate Burn™, pyruvate ester, pyruvate eyedrops, Pyruvate Fuel™, pyruvic acid, ringer's ethyl pyruvate, sodium pyruvate.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
Alcoholic liver disease (Grade: C)
Research results regarding the use of pyruvate for alcoholic liver disease is inconclusive. Further research is needed.
Chronic obstructive pulmonary disease (COPD) (Grade: C)
Research results regarding the use of pyruvate for chronic obstructive pulmonary disease are inconclusive. Additional research is needed in this area.
Congestive heart failure (Grade: C)
Research results regarding the use of pyruvate for congestive heart failure are inconclusive. Further research is needed.
Heart muscle protection during heart surgery (Grade: C)
Limited evidence suggests that the addition of pyruvate to cardioplegic solution may enhance the protection of heart muscle during heart surgery. Additional research is needed in this area.
High cholesterol (Grade: C)
Research results regarding the use of pyruvate for high cholesterol are inconclusive. Further research is needed.
Reducing body fat mass (Grade: C)
Research results regarding the use of pyruvate for reducing body fat mass are mixed. Additional research is needed in this area.
Skin conditions (hyperkeratotic skin conditions) (Grade: C)
Research results regarding the use of pyruvate for hyperkeratotic skin conditions are inconclusive. Further research is needed.
Exercise performance enhancement (Grade: D)
The evidence does not support the use of pyruvate for exercise performance enhancement.