Phosphatidylserine is present in cell membranes and is the major molecule of its kind in the brain. Phosphatidylserine is essential for cell-to-cell communication and other cell functions.
Phosphatidylserine is present in greater amounts in animal-based foods, such as liver and kidneys, than in plants. Plant sources include soy beans, white beans, cabbage, carrots, whole-grain barley, and rice.
Phosphatidylserine is most commonly used for the treatment of central nervous system (CNS) disorders. It is commonly used to treat mental disorders ranging from age-associated memory impairment (AAMI) to Alzheimer's disease. Current evidence suggests that phosphatidylserine may benefit those with AAMI to a greater degree than it does those with Alzheimer's disease. However, more research is needed.
Ingestion of phosphatidylserine from bovine brain cortex (BC-PS) carries a risk of transmission of infectious disease, such as bovine spongiform encephalopathy (commonly known as mad cow disease). However, phosphatidylserine derived from soybeans (S-PS) does not carry that risk, and it appears to be equally effective as BC-PS.
Soy-derived phosphatidylserine (S-PS) is listed on the U.S. Food and Drug Administration (FDA) Generally Recognized as Safe (GRAS) list.

Related Terms

BC-PS, bovine cortex, cephalin, egg phosphatidylserine, egg-PS, E-PS, kephalin, phos serine, PS, soybean phosphatidylserine, soybean-PS, S-PS.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Age-related memory disorders (Grade: C)
Limited evidence suggests that phosphatidylserine (PS) may have a role in treating age-related memory disorders, including Alzheimer's disease. Further research is needed.
Stress (Grade: C)
Limited evidence has indicated that PS supplementation may have an effect on different types of stress. Further research is required before conclusions may be drawn.