Pantethine (D-bis-(N-Pantothenyl-B-aminoethyl)-disulfide)

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Pantethine is the active form of pantothenic acid and becomes coenzyme A in the body.
Some sources say that supplemental pantethine may not be stable and may need to be refrigerated, which is why vitamin B5 supplements are usually taken as calcium pantothenate.
Pantethine has been used to lower cholesterol and heart disease risk, as well as improve gland function and energy. However, more research is needed.

Related Terms

Bile acid sequestrant, bis-pantethine, bis-pantothenamidoethyl disulfide, calcium 4'-phosphopantothenate (CaPP), calcium pantothenate (CaP), carnitine, coenzyme A, coenzyme pantethine, cyproheptadine, cysteamine, D-bis-(N-Pantothenyl-B-aminoethyl)-disulfide, D-pantethine, pantetheine, pantetheinase, Pantetina, panthenol, pantomin, pantosin, pantothenic acid, sulfopantetheine, thiol pantethine, vitamin B5.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
High cholesterol (Grade: B)
Many studies have looked at the effects of taking pantethine by mouth on cholesterol levels. There is evidence that pantethine may reduce levels of total cholesterol and fatty acids. However, more high-quality research is needed.
Athletic performance (Grade: C)
Early studies suggest that a combination product containing pantethine may not be helpful in athletic performance. More research is needed before further conclusions can be made.
Constipation (Grade: C)
Early studies suggest that a combination of pantethine and magnesium oxide is often prescribed as a laxative for people who have constipation caused by taking some medications. Further study is needed to understand the effect of pantethine alone.
Cystinosis (Grade: C)
Pantethine has been studied for use in cystinosis, a disease caused by amino acid buildup. However, evidence is still lacking and more research is needed.
Fatty liver (Grade: C)
Early studies suggest that pantethine may reduce symptoms of fatty liver. More research is needed before conclusions can be made.
Heart disease (Grade: C)
The effect of pantethine on heart disease has been studied. More research is needed before conclusions can be made.