Ornithine alpha-ketoglutarate


Ornithine alpha-ketoglutarate (OKG) is not found naturally in the body. It is made from combining two amino acids, ornithine and alpha-ketoglutarate (AKG), which are thought to have important roles in metabolism.
OKG has been used for treating burns and wounds, to promote the production of muscle protein following trauma, stroke, or surgery, and to promote growth in children who are fed via intravenous tube for the long term (called long-term total parenteral nutrition, or TPN). It has been studied for recovery from major trauma or illness, as well as for brain disease. It is also often used to improve athletic performance or to build muscle, although more research is needed to confirm these effects.

Related Terms

2-Oxoglutaric acid, 2-oxopentanedoicic acid, 3-methylhistidine, AAKG, acétoglutarate (French), acide 2-oxoglutarique (French), acide a-cétoglutarique (French), acide alpha-cétoglutarique (French), AKG, alanine, alfa-cetoglutarato (Spanish), alpha keto glutarate, alpha ketoglutarate, alpha KG, alpha-cétoglutarate (French), alpha-cétoglutarate d'arginine (French), alpha-cétoglutarate de calcium (French), alpha-cétoglutarate de créatine (French), alpha-cétoglutarate de glutamine (French), alpha-cétoglutarate de L-arginine (French), alpha-cétoglutarate de L-leucine (French), alpha-cétoglutarate de taurine (French), alpha-cetoglutarate d'ornithine (French), alpha-ketoacid, alpha-ketoanalogs, alpha-ketoglutarate, alpha-ketoglutarate dehydrogenase (KGDHC), alpha-ketoglutarate-pyridoxine complex, alpha-ketoglutaric acid, alpha-ketoisocaproate, alpha-ketoisovalerate, alpha-ketomethylvalerate, ammonia, arginine, arginine alpha-ketoglutarate, arginine aspartate, calcium alpha-ketoglutarate (Ca-ket), cétoglutarate d'ornithine (French), Cetornan®, creatine alpha-ketoglutarate (creatine AKG), diarginine alpha-ketoglutarate, glutamate, glutamine, glutamine alpha-ketoglutarate, glycine, histidine, hydroxyproline, L-arginine, L-leucine alpha-ketoglutarate, L-lysine alpha-ketoglutarate reductase, L-ornithine alpha-ketoglutarate, L(+)-ornithine alpha-ketoglutarate, lysine, malate-oxalacetate, OAKG, OGO, OKG, Ornicetil®, ornithine, ornithine alpha-ketoglutarate, ornithine oxoglutarate, ornitina cetoglutarato (Spanish), oxoglutarate, phenylalanine, polyamines, proline, putrescine, pyridoxine AKG (PAK), pyruvate, pyruvic acid, spermine, spermidine, taurine alpha-ketoglutarate, tyrosine.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Burns (Grade: A)
Severe burn injury may lead to problems with metabolism, nitrogen imbalance, and low energy and protein reserves. Numerous studies suggest that OKG may help severe burn patients by regulating protein metabolism and maintaining nitrogen balance and nutritional status. Delivering OKG via a tube through the nose to the stomach may improve wound healing time and shorten the duration of tube feeding in burn patients.
Aging (Grade: C)
Early studies suggest that OKG may benefit elderly people who are ill. More research is needed.
Chemotherapy side effects (Grade: C)
Early studies suggest that OKG may prevent nausea and vomiting associated with chemotherapy, and that these benefits may equal those of the drug metoclopramide, in people who are treated with the cancer medications cisplatin or Adriamycin. More research is needed.
Coma (Grade: C)
In early studies, OKG had a lack of effect on coma associated with liver disease. Further research is needed before conclusions can be made.
Critical illness (Grade: C)
Research suggests that OKG therapy may help improve and balance nitrogen levels after an injury or trauma. OKG is known to enhance metabolism and improve cell immunity, as well as stimulate important hormones such as insulin and growth hormone. Further research is needed.
Encephalopathy (Grade: C)
Early studies show that OKG had a lack of benefit on brain disorders and worsened the condition of patients. The information that is available comes from low-quality studies. More research is needed before conclusions can be made.
Growth (Grade: C)
Early studies suggest that OKG may improve growth in children before puberty, but there is currently not enough evidence. More research is needed.
HIV support (Grade: C)
There are a limited number of studies involving the use of OKG for improving nutrition and immune function in HIV-positive people. More research is needed before conclusions can be made.
Pressure ulcers (Grade: C)
Early research suggests that OKG may benefit elderly people who have bedsores. More research is needed.
Recovery after surgery (Grade: C)
Few studies have looked at the potential benefits of OKG on recovery after surgery. Limited evidence suggests that OKG may improve the production of muscle protein during the recovery period. However, more research is needed.
Stroke recovery (Grade: C)
Few studies have looked at the effect of OKG in stroke recovery. There is some evidence that OKG may initially improve stroke recovery. More research is needed before conclusions can be made.