Nicotinamide

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Nicotinamide (also known as niacinamide) is chemically similar to niacin and, like niacin, is a form of vitamin B3. Nicotinamide and niacin are found in many foods, including vegetables, fruits, grains, meats, milk, and eggs.
Nicotinamide is approved by the U.S. Food and Drug Administration (FDA) for the prevention and treatment of pellagra, a vitamin B3 deficiency disease characterized by diarrhea, dermatitis, neurodegeneration, and dementia.
Nicotinamide has been investigated for the prevention of type 1 diabetes. It is included in skin care products for the treatment of acne and UV-induced immune suppression, and in products intended to enhance appearance.

Related Terms

3-Carbamoylpyridine, 3-pyridinecarboxamide, 3-pyridinecarboxylic acid amide, amid kyseliny nikotinove (Czech), amide PP, aminonicotin, amixicotyn, amnicotin, austrovit PP, Benicot, beta-pyridinecarboxamide, delonin amide, dipegyl, endobion, factor PP, hansamid, inovitan PP, m-(aminocarbonyl)pyridine, mediatric, NAD, NADH, NADP, NADPH, NAM, niacinamide, niamide, niavit PP, nicamide, nicamina, nicamindon, nicasir, Nicobion®, nicofort, nicogen, nicomidol, nicosan 2, nicosylamide, nicota, nicotamide, nicotilamide, nicotililamido, nicotinamida (Spanish), nicotinamidum (Latin), nicotine acid amide, nicotine amide, nicotinic acid amide, nicotinic amide, Nicotinsäureamid (German), nicotol, nicotylamide, nicotylamidum, nicovel, nicovit, nicovitina, nicovitol, nicozymin, niko-tamin, nikotinamid, Nikotinsäureamid (German), Nikotin(säure)amid (German), niocinamide, nizymin, papulex, pelmin, pelmine, pelonin amide, PP-faktor, pyridine-3-carboxylic acid amide, savacotyl, vi-nicotyl, vitamin B, vitamin B3, vitamin PP, witamina PP (Polish).

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
Pellagra (niacin) (Grade: A)
Nicotinamide is approved by the U.S. Food and Drug Administration (FDA) for use in the prevention and treatment of pellagra, a vitamin B3 deficiency disease.
Hyperpigmentation (Grade: B)
In preliminary research, nicotinamide decreased hyperpigmentation (darkening of patches of skin). Well-designed clinical trials are needed before a conclusion can be made.
Type 1 Diabetes mellitus: preservation of beta-islet cell function (Grade: B)
Preliminary data suggest that nicotinamide may prevent the onset of type 1 diabetes and prevent damage to the insulin-producing cells of the pancreas. Additional clinical research is needed before firmer conclusions can be made.
Acne (Grade: C)
Preliminary research suggests that nicotinamide, applied to the affected area, may help treat acne, with an effect similar to that of the antibiotic clindamycin. Additional research is needed before a conclusion can be made.
Autoimmune disorders (Grade: C)
Limited research suggests that mild pemphigus foliaceus, an autoimmune skin disorder, may respond to treatment with a combination niacinamide and the antibiotic tetracycline. Further research on the effect of niacinamide alone is needed before a conclusion can be made.
Cancer (Grade: C)
Results of human studies on the effectiveness of niacin in aiding cancer treatment are mixed. Additional research is needed before a conclusion can be made.
Dry skin (Grade: C)
Preliminary research suggests that nicotinamide may have beneficial effects on atopic dry skin. Additional research is needed before a conclusion can be made.
Hyperphosphatemia (Grade: C)
Preliminary research suggests that nicotinamide may reduce blood phosphorus levels in hemodialysis patients with hyperphosphatemia (high blood phosphorus level). Additional research is needed before a conclusion can be made.
Macular degeneration (Grade: C)
Preliminary research suggests that nicotinamide, in combination with antioxidants, improves macular function in people with macular disease (eye disease). Further research on the effect of nicotinamide alone is needed before a conclusion can be made.
Osteoarthritis (Grade: C)
Early research suggests that niacinamide may be useful to treat osteoarthritis. Further research is needed before a conclusion can be made.