MSM (Methylsulfonylmethane)


Methylsulfonylmethane, or MSM, is a form of organic sulfur that is found in many different fruits, vegetables, grains, and animals.
Evidence supporting the need for dietary MSM or the use of MSM as a source of dietary sulfur is lacking. MSM has been studied for its possible benefits for allergy symptoms affecting the nose, osteoarthritis, and antioxidant status. However, more research is needed.
MSM is generally well tolerated. However, studies on its long-term effects are lacking.

Related Terms

Crystalline DMSO, dimethyl sulfone, DMSO2, methyl sulfone, methyl sulfonyl methane, methyl-sulfonyl-methane, methylsulfonylmethane, MSM, MSM Relief, OptiMSM® 650mg, sulfonyl sulfur.
Combination product examples: AR7 Joint Complex (sternum collagen, methylsulfonylmethane, cetyl myristoleate, lipase, vitamin C, bromelain) (Robinson Pharma, Santa Ana, CA); FlexmaxTM Glucosamine with MSM (glucosamine sulfate potassium chloride, methylsulfonylmethane, maltodextrin, cellulose, stearic acid, modified cellulose, silica, glycerine); Flex-A-Min® Complete (glucosamine HCl, MSM, chondroitin complex, white willow, ginger, SAM-e, hyaluronic acid, collagen, Boswellia, citrus bioflavonoids); Osteo Bi-Flex: Plus MSM Smoothcap™ (glucosamine HCl, MSM/chondroitin complex, vitamin C, manganese, boron, microcrystalline cellulose, sodium carboxymethylcellulose, yellow 5 lake, crospovidone, magnesium stearate, yellow 6 lake, maltodextrin, dextrose, soy lecithin, sodium citrate, red 40 lake, blue 1 lake).

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Antioxidant (Grade: B)
Studies suggest that MSM may have antioxidant activity in people who exercise. More research is needed to determine the proper dose.
Osteoarthritis (Grade: B)
MSM has been studied in the treatment of osteoarthritis (OA), both alone and combined with glucosamine, with possible small benefit. More studies on MSM and its effects on osteoarthritis are needed.
Circulation problems (Grade: C)
Early research suggests that a combination treatment containing MSM may reduce swelling and oxidative stress in people who have circulation problems. However, the effects of MSM alone need to be determined, as it may increase swelling. More research is needed.
Hay fever (Grade: C)
Early research reports that MSM may help reduce hay fever symptoms. However, higher-quality studies are needed to confirm these findings.
Skin conditions (Grade: C)
A combination treatment containing MSM has been studied for possible effects on skin redness, itching, color, and bumps. However, the effects of MSM alone need to be determined. More research is needed.