Manganese is an essential trace nutrient. The human body contains about 10 milligrams of manganese, which is stored mainly in the liver, kidneys, pancreas, and bones.In the human brain, manganese is bound to manganese metalloproteins. Manganese activates enzymes responsible for the use of several key nutrients, including B vitamins (biotin, thiamin), vitamin C, and choline. It aids in the synthesis of fatty acids and cholesterol, facilitates protein and carbohydrate metabolism, and may also participate in the production of sex hormones and maintaining reproductive health.
Manganese has been examined as a treatment for a variety of conditions, including osteoarthritis and wound healing. However, manganese is often used in combination with other vitamins and/or minerals. Therefore, the effects of manganese alone are difficult to determine.
Chronic exposure to excessive manganese levels can lead to a variety of psychiatric and motor disturbances, termed manganism.

Related Terms

Manganese ascorbate, manganese chloride, manganese cofactors, manganese gluconate, manganese metalloproteins, manganese sulfate, manganese-containing polypeptides, Mn.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Antispasmodic (Grade: C)
The combination of manganese-cobalt oligosol may have an effect on muscle relaxation. Additional studies are needed in this area.
Chronic obstructive pulmonary disease (COPD) (Grade: C)
Selenium, manganese, and zinc plasma levels may aid mechanical ventilation in patients with chronic obstructive pulmonary disease (COPD). Additional studies are needed.
Dental caries (Grade: C)
The effects of toothpaste containing manganese chloride on dental cavities has been studied. However, results are unclear and additional studies are needed.
Growth (Grade: C)
The effects on growth of manganese in combination with other vitamins or minerals have been examined. The role of manganese alone cannot be determined. Additional studies are needed.
Hepatitis (alcoholic) (Grade: C)
N-acetyl cysteine, vitamins A-E, biotin, selenium, zinc, manganese, copper, magnesium, folic acid, and coenzyme Q in combination showed a lack of effect on alcoholic hepatitis. Additional studies are needed in this area.
Osteoarthritis (Grade: C)
Manganese ascorbate in combination with sodium chondroitin sulfate and glucosamine has demonstrated benefit in patients with osteoarthritis. However, the role of manganese alone cannot be determined from these studies. Additional studies are needed.
Osteoporosis (Grade: C)
Supplemental calcium and trace minerals (copper, manganese, and zinc) increased bone mineral density in postmenopausal women. However, the effects of manganese alone cannot be determined. More research is needed in this area.
Premenstrual syndrome (Grade: C)
A combination of calcium and manganese may alleviate symptoms associated with premenstrual syndrome. However, the effects of manganese alone cannot be determined. Further research is needed.
Weight loss (Grade: C)
A combination of 7-oxo-DHEA, l-tyrosine, asparagus root extract, choline bitartrate, inositol, copper gluconate, manganese, and potassium iodide has been examined for its effects on weight loss. Additional research is needed in this area.
Wound healing (Grade: C)
Manganese in combination with calcium and zinc may be beneficial in patients with chronic wounds. Additional research is needed in this area.