Mitragyna speciosa is a tree found in Southeast Asia. It acts on the central nervous system, affects brain function, is known to have pain-relieving, mood-enhancing, and cough-reducing effects, and has been used as an opium substitute.
It is also called kratom and has been identified as an herb of recreational drug abuse. People who use it over the long term may develop an addiction and symptoms of withdrawal when they stop using it. Many countries and states have passed laws to make Mitragyna speciosa illegal, but people may still easily obtain it over the Internet. Unintentional death has occurred following use of krypton, a combination product containing Mitragyna speciosa and O-desmethyltramadol.
There is not enough evidence to support the medical use of Mitragyna speciosa.
7-Hydroxymitragynine, 9-O-demethyl paynantheine, 9-O-demethyl-16-carboxy paynantheine, 9-O-demethyl-17-carboxy-16,17-dihydro paynantheine, 9,17-O-bisdemethyl paynantheine, 9,17-O-bisdemethyl-16,17-dihydro paynantheine, 16-carboxy paynantheine, 17-O-demethyl paynantheine, 17-O-demethyl-16,17-dihydro paynantheine, 17-carboxy-16,17-dihydro paynantheine, biak, biak biak, isopaynantheine, ithang, kakuam, ketum, krathom, kratom, krypton, Mitragyna speciosa, Mitragyna speciosa Korth., mitraciliatine, mitragynine, mitraphylline, paynantheine, Rubiaceae (family), speciociliatine, speciogynine, thang, thom.
Combination product examples: Krypton (kratom, O-desmethyltramadol).
Note: The cultivation, sale, and possession of Mitragyna speciosa are illegal in some countries. Unintentional death has occurred following ingestion of krypton, a combination preparation containing Mitragyna speciosa and O-desmethyltramadol.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.