Hyaluronic acid


Hyaluronic acid is polysaccharide (sugar-based) component of connective tissue, including the skin. Its water-binding and elastic properties have skin-plumping effects. Hyaluronic acid also lubricates tissues and joints.
Hyaluronic acid is used in osteoarthritis treatment, ophthalmic (eye) surgery, and tissue engineering. It may be injected into a joint or into the skin, taken by mouth, or applied topically. Hyaluronic acid fillers are popularly used to minimize the appearance of facial wrinkles and to plump skin in the cheeks and chin.

Related Terms

Biolon™, Curiosin®, Cystistat®, dermal fillers, DermaLive®, Durolane®, Euflexxa™, Eyestil®, glycosaminoglycan, Healon®, Healon 5®, Healon GV®, Hyalgan®, hyaluron, hyaluronan, hyaluronate, Hylaform®, Hylaform Plus®, hylan, hylan G-F 20, hylan polymers, Hylira IPM Wound Gel™, Juvéderm™, Juvéderm 24HV™, Juvéderm 30™, Juvéderm 30HV™, Juvéderm Ultra™, Juvéderm Ultra Plus™, Orthovisc®, Perlane®, Provisc®, Restylane®, sodium hyaluronate, Supartz™, Suplasyn®, Synvisc®, Vitrax®.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Aging skin (Grade: B)
Results of human study showed that a hyaluronic acid product, Juvéderm Ultra Plus®, reduced the appearance of nasolabial folds (creases between the nose and lips) more so than a bovine collagen-based filler. Additional research is needed to confirm these early findings.
Dry eye syndrome (Grade: C)
Early human study showed that a hyaluronic acid preparation, applied to the eye, reduced symptoms of dry eye syndrome and was well tolerated. Additional studies are needed.
Osteoarthritis (Grade: C)
Intra-articular (intrajoint) hyaluronic acid injections have been reported to be highly effective in the treatment of osteoarthritis in humans. A small study also found that oral hyaluronic acid therapy helped reduce pain and increase physical functioning in adults with knee osteoarthritis. Additional research is needed in this area.