Hesperidin

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Hesperidin is a flavonoid found in citrus fruits such as lemons, oranges, and grapefruits before they ripen. Hesperidin is available as a supplement, both alone and in combination products with other ingredients. Scientific studies of the effects of hesperidin have used these combination products. As a result, conclusions about the effects of hesperidin alone cannot be made based on the available studies.
Hesperidin may have antioxidant and antimicrobial properties. It may have effects on the immune system and help prevent disease. The combination products that contain hesperidin and other ingredients may have beneficial effects on blood vessels.

Related Terms

Alpha-glucosylhesperidin, bioflavonoids, citrus flavonoids, Dangyooja (Citrus grandis Osbeck), flavanones, flavonoid glycosides, flavonoids, G-hesperidin, glucosyl hesperidin, hesperidin, hesperidin-7-O-rutinoside, hesperidin-7-rhamnoglucoside, hesperidin-7-rutinose, hesperidin-7-rutinoside, hesperidin glycoside, hesperidin methyl chalcone (HMC), hesperidine methylchalcone, Kjool (Citrus unshiu Marcow), micronized purified flavonoid fraction, MPFF, neohesperidin, rhamnoglucosides, trimethyl-hesperidin-chalkon, vitamin P, Yuza (Citrus junos Sieb. ex Tanaka).
Select combination products: 5682 SE, Alvenor®, Ardium®, Arvenum 500®, Capiven®, Daflon® 500mg, Detralex®, Elatec®, Rikkunshito, S 5682, Venotec®, Venitol® (micronized purified flavonoid fraction containing diosmin and flavonoids (hesperidin, isorhoifolin, linarin, disometin)), Cyclo 3 Fort®, Great Legs (Ruscus aculeatus root extract, hesperidin methyl chalcone and ascorbic acid). Diosmin Complex® (diosmin and hesperidin) has been deemed qualitatively and quantitatively identical to other branded diosmin/hesperidin formulations available outside the United States.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
Chronic venous insufficiency (CVI) (Grade: A)
Combination products containing hesperidin, hesperidin methyl chalcone (HMG), ascorbic acid, diosmin, and other ingredients may improve the symptoms of CVI. Additional research on the effect of hesperidin alone is needed before a firm conclusion may be drawn.
Hemorrhoids (Grade: A)
The combination product micronized purified flavonoid fraction (MPFF), which contains hesperidin and the flavonoid diosmin, may improve symptoms of hemorrhoids. Additional research on the effect of hesperidin alone is needed.
Venous leg ulcers (Grade: B)
The combination product micronized purified flavonoid fraction (MPFF), which contains hesperidin and the flavonoid diosmin, may improve symptoms of venous leg ulcers when used together with routine ulcer care. Additional research on the effect of hesperidin alone is needed before a firm conclusion may be drawn.
Arthritis (Grade: C)
In early study, a hesperidin derivative was found to improve symptoms of arthritis. Additional research is needed before a conclusion can be made.
Blood vessel disorders (Grade: C)
The combination product micronized purified flavonoid fraction (MPFF), which contains hesperidin and the flavonoid diosmin, may improve symptoms of capillary fragility, or easily damaged small blood vessels. Additional research on the effect of hesperidin alone is needed.
Diabetes (Grade: C)
Micronized purified flavonoid fraction (MPFF), which contains the flavonoid diosmin in addition to hesperidin, may help lower blood sugar in women with type 2 diabetes. Additional research on the effect of hesperidin alone is needed before a firm conclusion may be drawn.
Lymphedema (swelling due to blockage of the lymph nodes) (Grade: C)
A combination product (Cyclo 3 Fort®) containing