Fermented wheat germ extract


Wheat germ is the nutrient-rich embryo of the wheat kernel, or seed. Wheat germ is high in protein and provides essential vitamins and minerals, such as potassium, iron, B vitamins, zinc, and vitamin E. The wheat germ constitutes approximately 2.5% of the total weight of the wheat kernel.
Fermented wheat germ extract (FWGE, Avemar pulvis) was invented by Hungarian biochemist Mate Hidvégi in the early 1990s. In the United States, FWGE is marketed as a dietary supplement, Avé®, by American BioSciences, Inc. (Blauvelt, NY). FWGE is manufactured as Avemar® in Hungary, where it is approved as a "medical nutriment" for cancer patients.
Scientific evidence suggests that FWGE may have anticancer effects. FWGE may also improve immune function-associated conditions such as rheumatoid arthritis and systemic lupus erythematosus.

Related Terms

2,6-Dimethoxy-p-benzoquinone, antioxidant biofactor (AOB), Avé©, AVE, Avé®, Avemar® (MSC), Avemar pulvis, catechins, extract of Triticum vulgare germ, extract of wheat germ, fermented wheat germ extract (FWGE), flavanoids, MSC, n-octacosanol, octacosanol, octacosyl alcohol, OncoMar™, phytic acid, rutin, Triticum aestivum germ extract, wheat bran, wheat germ agglutinin.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Chemotherapy adverse effects (Grade: C)
Limited research suggests that fermented wheat germ extract (FWGE) may improve the adverse effects of chemotherapy. Further studies are required before conclusions may be drawn.
Colorectal cancer (Grade: C)
Preliminary data suggest that FWGE may improve the overall survival rate of patients with colorectal cancer. Additional well-designed studies are required before a conclusion can be made.
Rheumatoid arthritis (Grade: C)
Limited research suggests that FWGE may improve joint tenderness and morning stiffness. Additional data are needed before a conclusion may be made.
Skin cancer (Grade: C)
Preliminary research suggests that FWGE may improve the symptoms of melanoma and overall survival of melanoma patients. Further research is needed before a conclusion can be made.