Cyclo(His-Pro) is a naturally occurring molecule found in the brain, spinal fluid, and blood. It was first discovered in 1976 in the hamster hypothalamus, the region of the brain that regulates hunger, thirst, and body temperature.
Cyclo(His-Pro) has been used as a dietary supplement. Limited research suggests that consuming cyclo(His-Pro) and zinc may help reduce blood sugar levels. However, more evidence is needed before conclusions can be made on the use of this supplement in improving blood sugar control.
Preliminary evidence has found that cyclo(His-Pro) may improve zinc absorption and aid in wound healing and immune function, particularly in diabetic patients. Although confirmation is needed, supplementation with cyclo(His-Pro) plus zinc is a promising treatment for high blood sugar.

Related Terms

C(HP), C.HP, cHP, CHP, cyclo (His-Pro), Cyclo (his-pro), Cyclo [His-Pro], cyclo His-Pro, cyclo-(His-Pro), cyclo-[His-Pro], cyclo-his-pro, cyclo-His-Pro, cyclo(his-pro), cyclo(His-Pro), cyclo(HIS-PRO), cyclo[His-Pro], (cyclo)-His-Pro, cyclo(histidyl-proline), cyclo(Histidyl-Proline), His-Pro diketopiperazine, histidine-proline diketopiperazine, histidyl proline diketopiperazine, histidyl-proline, histidyl-proline diketopiperazine, Histidyl-proline diketopiperazine, Histidyl-Proline diketopiperazine, Histidyl-Proline Diketopiperazine, histidyl-proline-diketopiperazine, histidylproline diketopiperazine.
Combination product examples: MidecoseĀ® (cyclo(His-Pro), amino acid chelated zinc, amino acid chelated chromium, inositol).

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.