Collagen type II


Collagen is the most abundant protein in mammals. It is the main component of cartilage, skin, ligaments, tendons, bone, and teeth. More than 29 different types of collagen have been described. The most common forms in the human body are types I, II, III, and IV.
Type II collagen is responsible for strength and toughness in the cartilage. This type of collagen is found in the joints, breastbone, and respiratory tract.
Type II collagen accounts for over 50 percent of the dry weight of cartilage and is also found in small amounts in a number of tissues during early development.
Preliminary evidence suggests that type II collagen may help relieve the pain of osteoarthritis (OA) and rheumatoid arthritis (RA). Some studies found that a product containing type II collagen may provide short-term pain relief for osteoarthritis patients. However, more evidence is needed before conclusions can be made regarding the use of type II collagen for any health condition.

Related Terms

Articular cartilage, Bio-Cell Collagen II®, bovine collagen II, CII, cartilage, chicken collagen II, chondroitin, CII, Collagen II (Natrol®), Colloral®, C-telopeptide, CTX-II, gelatin, glucosamine, glycosaminoglycans (GAGs), hyaluronan, Kolla2® (Collagen Nutraceuticals, Inc.), Maxilife Chicken Collagen Type II (Twinlab®), Rheumatoid Tolerance Factor: Type II Collagen Caps (Pharmax Inc.), triple helical collagen type II, uCTX-II, unhydrolyzed chicken sternum cartilage collagen type II, urinary C-terminal crosslinking telopeptide.
Note: This monograph is limited to type II collagen. This monograph does not include hydrolyzed collagen (also called HCP, hydrolysate, collagen peptide, gelatin, gelatin hydrolysate, and hydrolyzed gelatin), which is made predominantly from type I collagen.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Osteoarthritis (Grade: C)
Preliminary evidence suggests that a nutritional supplement containing type II collagen may provide short-term pain relief for osteoarthritis patients. Additional studies are needed before conclusions can be made.
Rheumatoid arthritis (Grade: C)
Type II collagen taken by mouth may reduce joint inflammation associated with rheumatoid arthritis. Further research is required to test the effectiveness of this treatment approach.