Cissus quadrangularis


Cissus quadrangularis is a vine native to Africa, Southeast Asia, and India. Historically, Cissus quadrangularis was used for bone health, pain relief, and stomach conditions.
Traditionally, parts of the Cissus plant have been mashed, roasted, juiced, pulped, or cooked before application. In modern times, Cissus quadrangularis has been taken as a powder or capsule.
Cissus quadrangularis has been studied for its potential to treat osteoporosis and obesity. Additional research on these topics is needed.

Related Terms

3,3',4,4'-Tetrahydroxybiphenyl, 6-O-[2,3-dimethoxy]-trans-cinnamoyl catalpol, 6-O-meta-methoxy-benzoyl catalpol, ascorbic acid, asthisonhara, beta-sitosterol, beta-sitosterol glycoside, calcium, carotene, carotenoids, chadhuri, chaudhari, cissus, cissus extract, cissus formula, cissus formulation, C. quadrangularis, Cissus quadrangularis extract, Cissus succulent, Cissus tetragona, CQ, CQE, CQR-300, cysteine proteases, delta-amyrin, delta-amyrone, epifriedelinol, flavonoids, hadjod, hadjora, harbhanga, harsankari, hasjora, indanes, iridoids, isinwasi (Zulu), isoarborenol, kandavela, ketosteroids, kun koat (Thai), lupenone, mangaroli, nalleru, namunungwa, onocer-7-ene-3alpha,21beta-diol, pallidol, phet cha sung khaat, phet sang kat, phet sang khat (Thai), phet sangkhat, phytosterols, picroside-1, pirandai, polyphenols, quadrangularin A, quadrangularis, quercitin, quercitrin, sam roi tow (Thai), samroi to, san cha khuat, san cha koat (Thai), stemmed vine, stilbenes, tannins, triterpenoids, vajravalli, vedhari, veld grape, veld grave vine, veldt-grape, vitamin C, vitamin E, vitis, vitis quadrangularis, winged treebine.
Select combination products: Calzbone® extract (containing Cissus quadrangularis, boswellia, vitamin D, and calcium), CORE™ (containing Cissus quadrangularis, ChromeMateTM [niacin-bound 10% chromium concentrate], green tea extract, selenium, AbumaSoyTM [soy albumin], vitamin B6, vitamin B12, and folic acid), Cylaris™ (containing Cissus quadrangularis, ChromeMateTM [niacin-bound 10% chromium concentrate], green tea extract, selenium, soy albumin extract, vitamin B6, vitamin B12, and folic acid).
Note: The Cissus quadrangularis plant is referred to by several other names, such as Cissus succulent, Cissus tetragona, Vitis quadrangularis, and Vitis succulent. However, Cissus quadrangularis will be the principal name used throughout the remainder of this monograph.
Though other species of Cissus have been previously studied, such as Cissus assamica, Cissus deblis Planch., Cissus hamaderohensis, Cissus ibuensis Hook, Cissus pteroclada, Cissus populnea, Cissus repens, Cissus rheifolia, Cissus rotundifolia, Cissus rubiginosa, Cissus rufescens, Cissus sicyoides, and Cissus verticillata, the intent of this monograph will be to focus solely on Cissus quadrangularis.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Obesity/weight loss (Grade: B)
may decrease body weight, body fat, and waist circumference. Additional research is needed in this area.
Broken bones (Grade: C)
Limited research suggested that a combination product containing
Dental conditions (Grade: C)
The effect of
Hemorrhoids (Grade: C)
Limited research suggests