Bifidobacterium longum BB536

background

Bifidobacterium longum BB536 (BB536) is a Gram-positive bacterium that produces lactic and acetic acids. BB536 is a type of probiotic bacterium. Probiotics are beneficial bacteria (sometimes referred to as "friendly germs").
The supposed health benefits of probiotics and BB536 include maintaining the health of the intestinal tract and the immune system and protecting against infection.
At this time, research in support of the use of BB536 for allergic disorders is limited mainly to Japanese cedar pollen (JCP). Studies suggest that BB536 and other probiotics may improve bowel function and fecal characteristics. BB536 as part of infant formulas may offer small benefit.
Further research is needed to assess the potential benefits of BB536.

Related Terms

BAA-999, BB536, BB-536, Bifidobacterium longum NCC3001, bifidus milk, bifidus yogurt, BL999, Morinaga Bifidus®, Morinaga Caldus®, oligodeoxynucleotide (ODN) BL07S.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
Allergies (Grade: B)
Research suggests BB536 may reduce symptoms associated with Japanese cedar pollen (JCP) allergy. At this time, there is limited information available on other types of allergies. Additional research is needed in this area.
Constipation (Grade: C)
The addition of BB536 to the diet, either alone or in combination with other prebiotics, normalized bowel movements and improved moisture, odor, and visual characteristics of feces. BB536 supplementation has also changed bacterial strains in human intestines.
Flu (Grade: C)
A study showed that BB536 reduced the number of vaccinated people who got the flu or a fever. Additional research is needed in this area.
High cholesterol (Grade: C)
Fermented milk with BB536 and other beneficial bacteria may reduce LDL ("bad") cholesterol and HDL ("good") cholesterol. Additional research is needed in this area.
Infant development / neonatal care (Grade: C)
BB536 may shorten the time to reach full tube feeding in very-low-birthweight infants. Other studies have suggested that formulas with BB536 do not negatively affect growth or development. Additional research is needed in this area.
Ulcerative colitis (inflammation of the large intestine) (Grade: C)
Milk containing BB536 and other probiotics increased bowel movements and improved moisture, odor, and visual characteristics of feces. BB536 supplementation has also changed bacterial strains in human intestines. Additional research using BB536 alone is needed.
Yeast infection (Grade: C)
Research suggests that BB536 and other probiotics may reduce yeast infections associated with chemotherapy. BB536 has also benefitted fecal bacterial populations. Additional research using BB536 alone is needed.