Baikal skullcap (Scutellaria barbata)

background

Baikal skullcap (Scutellaria baicalensis) is a perennial herb native to southern China and throughout Korea. Scutellaria baicalensis is one of approximately 350 Scutellaria species.
Scutellaria baicalensis root is widely used in China as an adjuvant to chemotherapy for lung cancer. It is also commonly used in herbal medicine in Japan. Early studies have found that Scutellaria baicalensis may have anticancer properties. However, there is little clinical evidence. In Western herbalism, Baikal skullcap is also known as an ingredient in PC-SPES, used for prostate cancer.
Traditional uses include antibacterial, anticancer antifungal, anti-inflammatory, antiviral, and neuroprotective. Strong supportive evidence for Scutellaria baicalensis for any use is lacking at this time.
Warning: Scutellaria baicalensis is an ingredient in PC-SPES, which has been recalled from the U.S. market due to possible contamination; PC-SPES should not be used.

Related Terms

1-Octen-3-ol, 2',3',5,7-tetrahydroxy flavone, 2',5,6',7-tetrahydroxyflavanonol (THF), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7.8%), 5,6,7,3',4'-pentahydroxy flavanone-7-O-glucuronide, 5,6,7-trimethylbaicalein, 5,7,2',6'-tetrahydroxyflavone, 5,7,2'-trihydroxyflavone, 6,7-di-O-nicotinoylscutebarbatine G, 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine A, 6-O-acetylscutehenanine A, 6-O-methyl-baicalin-7-O-beta-glucopyranuronoside, 6-O-nicotinoyl-7-O-acetylscutebarbatine G, 6-O-nicotinoylscutebarbatine G, (6S,9R)6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one, 7-D-glucuronic acid-5,6-dihydroxy-flavone, (11E)-6alpha-acetoxy-7beta,8beta-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2), (13R)-6alpha,7beta-dihydroxy-8beta,13-epoxy-11beta-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1), amino acids, Antoksyd S (C/E/XXI), Antoxid, apigenin, baicalein, baicalein 6-O-beta-glucopyranuronoside, baicalein 7-D-beta-glucuronate, baicalin, ban-ji-ryun (Korean), banjiryun (Korean), ban-zhi-lian (Chinese), berberine, BZL101, caicalin, carthamidin, Chinese skullcap, chrysin, chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside, cinnamate 4-hydroxylase (SbC4H), ethyl-7-O-apigenin-glucuronate, flavonoidglycoside, flavonoids, glucan S b RP-1?, herba Scutellariae barbatae, hexahydrofarnesylacetone, huang-qin, huangqin, isocarthamidin, Lamiaceae (family), luteolin, menthol, minerals, neobaicalein, neoclerodane diterpenoids, neoderodane diterpenoids, organic acids, oroxylin A, oroxylin A-7-O-glucuronide, PC-SPES, phenylalanine ammonia-lyase isoforms (SbPAL1, SbPAL2, and SbAPL3), (S)-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydro-4H-pyran-4-one, SBJ, Scutelleria baicalensis spp., Scutellaria barbata spp., Scutellaria rivularis Wall., scute, scute root, skullcapflavone, trihydroxyflavone, viscidulin III, water-soluble polysaccharides (WSPS'-1, WSPS'-2, and WSPS'-3), wogoninglucuronide, wogonoside.

evidence table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
 
Arthritis (Grade: C)
Traditional uses of Baikal skullcap include pain and inflammation. Preliminary research suggests no effect from a product for arthritis containing Baikal skullcap. Further research is required.
Attention-deficit hyperactivity disorder (ADHD) (Grade: C)
Traditional uses of Baikal skullcap include brain protection. Preliminary research suggests no effect from a product for minimal brain dysfunction containing Baikal skullcap. Additional research is needed before a conclusion can be drawn.
Cancer (Grade: C)
Traditional uses of Baikal skullcap include cancer treatment. It is a common ingredient in traditional Chinese medicine products. Preliminary research suggests some immunological changes with use in cancer patients. Further research is required.
Hepatitis B (Grade: C)
Traditional uses of Baikal skullcap include liver protection. Preliminary research suggests that some preliminary benefit was associated with a product containing Baikal skullcap with respect to hepatitis B. Additional research is needed before a conclusion can be drawn.