Testosterone prohormones, such as androstenediol, androstenedione, and dehydroepiandrosterone (DHEA), have been marketed as testosterone-enhancing and muscle-building nutritional supplements for the past decade. They have recently become more readily available in many countries through the Internet.
Androstenediol and other prohormones have been shown to increase androgen prohormone, testosterone, and estradiol levels in humans. However, despite promotional claims, studies have not demonstrated bodybuilding or sexually enhancing effects with prohormone supplements like androstenediol.
Research suggests that androstenediol may be less effective when taken by mouth.
Prohormone supplements, including androstenediol, are associated with potentially harmful side effects, including abnormal estrogen, testosterone and lipid levels, and the potential to contribute to cancerous cell growth.
Due to a lack of human benefit and the potential for negative health effects, the risk to benefit ratio of using androstenediol and other prohormone substances seems unfavorable. Prohormones are currently on the International Olympic Committee's list of banned substances and are banned from many professional athletic sports. Moreover, some forms have been banned for over-the-counter sales by the U.S. Food and Drug Administration (FDA). Androstenediol is not currently listed on the FDA everything added to food in the United States (EAFUS) database, which contains ingredients added directly to food that the FDA has either approved as food additives or listed or affirmed as generally regarded as safe (GRAS).
1,5alpha-Androsten-3,17-dione (1AD), 1,5alpha-androsten-3beta,17beta-diol, 19-norandrostenediol, 19-norandrostenedione, 3beta,17beta-androstenediol (AD), 4-androstenediol, 5-androstenediol, (Adiol), alpha-androstenediol, "Andro" prohormones, androstenediol 3-sulfate (ADIOLS), androstenediol glucuronide (3alpha-diol-G), androstenedione, beta-androstenediol, dehydroepiandrosterone, DHEA metabolite, methyl androstenediol.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Androgen prohormones are widely promoted for their effects on building lean body mass, reducing body fat, and enhancing physical endurance. Androstenediol and other prohormones have been shown to increase testosterone and estradiol levels in humans. However, significant improvements in muscle mass and athletic performance have not been observed in human studies.