American pawpaw (Asimina triloba) is a fruiting tree native to North America. However, plantings of the tree can be found in Asia, Australia, and Europe. Pawpaw extract is made from the twigs of the tree.
In the 1980s and 1990s, researchers at Purdue University isolated compounds from pawpaw bark extracts. Many of these compounds were found to have cytotoxic effects on cancer cell lines. Currently, there is a lack of available scientific evidence supporting the safety or effectiveness of pawpaw for any condition.
Acetogenin, alkaloids, American paw paw, annomontacin, Annonaceae (family), Annonaceous acetogenins, Annona cherimola, Annona diversifolia, Annona glabra, Annona muricata, Annona palustris, Annona purpurea, Annona reticulata, Annona squamosa, Annona squamosa X A. cherimola, Annona triloba L., annonacin, annonacin-A, asimicin, asimin, Asimina incarna, Asimina longifolia, Asimina obovata, Asimina parviflora, Asimina pygmaea, Asimina reticulata, Asimina tetramera, Asimina triloba (L.) Dunal, Asimina X nashii, asiminacin, asiminecin, asiminocin, asimitrin, asimilobin, asitrocin, asitrilobins, atemoya, benzyltetrahydroisoquinolone alkaloids, biriba, Brazilian pawpaw, bullanin, bullatacin, bullatacinone, bullatetrocin, bulletin, Carica papaya, cherimoya, coumaroyltyramine, custard apple, Deeringothamnus rugelii, Deeringothamnus puchellus, Disepalum, dog banana, dwarf pawpaw, feruloyltyramine, flag pawpaw, flavonoids, gigantetrocinone, Goniothalanus, graviola, guanabana, Hoosier banana, ilama, Indiana banana, isoannonacin, murisolinone, nicotiflorine, octanoate, opossum pawpaw, Ozark banana, papaya, paw paw, Paw Paw Cell-Reg®, poor man's banana, prairie banana, Rollinia mucosa, rutin, soncoya, soursop, squamolone, sugar apple, sweetsop, syringaresinol, trilobacin, trilobalicin, Uvaria, West Virginia banana, xylomaticin, Xylopia.
Note: American pawpaw (Asimina triloba) is not a papaya and should not be confused with Carica papaya or Annona muricata (graviola) although the species have similar common names and may be called "pawpaw."
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Pawpaw extract may have some anticancer activity, but additional study is needed to make a firm recommendation.
Pawpaw extract in combination with thymol and tea tree oil in a shampoo formulation may be effective for the eradication of lice. Better-quality study using pawpaw alone is needed before a firm recommendation can be made.