Cri du chat syndrome

background

Cri du chat (cri-du-chat) syndrome (French for "cry of the cat") is a medical condition that occurs when a person is born missing part of chromosome five. The disorder, also called 5p- syndrome, is characterized by a cat-like cry during infancy, intellectual disabilities (formerly called mental retardation), and delayed development.
It is estimated that cri du chat affects one out of 20,000-50,000 people. The disorder is slightly more common in females than males.
Some children with cri du chat syndrome are also born with heart defects, which range from mild to life-threatening. About 10% of infants with cri du chat syndrome die as a result of complications associated with heart defects, decreased muscle tone, and feeding difficulties.
There is currently no cure for cri du chat syndrome, but many treatments and therapies may help patients cope with the disorder. With appropriate therapy, some patients are able to live independently once they become adults, while others may need lifelong support and/or residential care. Adults with profound intellectual disabilities usually require lifelong nursing care.

Related Terms

5p minus syndrome, 5p- syndrome, cat cry syndrome, CdCs, chromosome 5p deletion syndrome, congenital heart defects, cri-du-chat, endocardial cushion defect, hypotonia, intellectual disabilities, isolated patent ductus arteriosus, Le Jeune's syndrome, microcephaly, monosomy 5P, secundum atrial septal defect, tetralogy of Fallot, ventricular septal defect.