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Active cancer (treatment within last 6 months or palliative)
Calf swelling >3 cm compared to other calf (measured 10 cm below tibial tuberosity)
Collateral superficial veins (non-varicose)
Pitting edema (confined to symptomatic leg)
Swelling of entire leg
Localized pain along distribution of deep venous system
Paralysis, paresis, or recent cast immobilization of lower extremities
Recently bedridden > 3 days, or major surgery requiring regional or general anesthetic in past 12 weeks
Previously documented DVT
Alternative diagnosis at least as likely
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