Chronic granulomatous disease

background

Chronic granulomatous disease (CGD) is a rare, inherited abnormality of certain cells of the immune system, known as phagocytic cells. The phagocytes do not function properly and are unable to kill harmful bacteria and fungi in CGD patients. Consequently, CGD patients suffer from repeated bacterial and fungal infections. Another common characteristic of the disease is granulomata (tumor-like masses of inflammatory tissue), which develop in many organs in response to chronic inflammation.
This disease was first discovered in 1959, and it was called "a fatal granulomatosis of childhood."
The exact number of CGD cases in the United States is unknown. However, the data from a recently established national registry suggest that the incidence of CGD in the United States is about one case per 200,000-250,000 people. Up to 20 patients are born with CGD each year, and there does not appear to be a racial or ethnic predilection.

Related Terms

Bacterial infections, bone marrow, fatal granulomatosis of childhood, fungal infections, gene therapy, genetic disorder, granulomas, granulomatosis, granulomatous disease of childhood, immunoglobulins, immune system, infection, inflammatory tissues, leukocytes, NBT, neutrophils, nitroblue tetrazolium test, phagocytic, phagocytes, progressive septic granulomatosis, X chromosome, X-linked chromosome, white blood cells.