David Irwin
Penn Neuroscience Center - Neurology
Office
(215) 316-5151
Fax (215) 349-5579 3400 Civic Center Boulevard South Pavilion, 2nd Floor Philadelphia, PA 19104
About
My research program focuses on the interface of clinical symptoms and underlying neuropathology in neurodegenerative disease. The purpose of this approach is to better identify clinically, pathologically and genetically homogeneous patient populations for inclusion into clinical trials to efficiently study emerging disease modifying treatments that target the pathogenic proteins specific for each neuropathological subtype of disease (e.g. FTLD-associated with tau or TDP-43 protein inclusions). Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
David Irwin
My clinical focus is on cognitive neurology and neurodegenerative disease including frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. I have a particular interest in young-onset dementia and the behavioral variant of frontotemporal dementia.My research program focuses on the interface of clinical symptoms and underlying neuropathology in neurodegenerative disease. The purpose of this approach is to better identify clinically, pathologically and genetically homogeneous patient populations for inclusion into clinical trials to efficiently study emerging disease modifying treatments that target the pathogenic proteins specific for each neuropathological subtype of disease (e.g. FTLD-associated with tau or TDP-43 protein inclusions). Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Primary Specialty
Neurologist
Practice
Penn Neuroscience Center - Neurology
Gender
Male
Education
Drexel University Center City Hahnemann Campus
Training
Hahnemann University Hospital
Accepting New Patients
Insurances Accepted
Aetna US Healthcare, Centivo Health Plan, Cigna, Cigna HealthSpring, Clover Health Plan, Devon Health Services (Americare), Gateway Health Plan, Geisinger Health Plan, Geisinger Medicaid, Global Medical Management, HealthAmerica / HealthAssurance, a Coventry Plan, HealthPartners, HealthPartners Medicare, HealthSmart, Highmark Blue Shield, Homestead Smart Health Plans/Claim Watcher, Horizon Blue Cross Blue Shield of New Jersey, Humana / Choicecare, Humana / Medicare, Imagine Health 360, Independence Blue Cross (Keystone East), Keystone First, Keystone First Medicare, Multiplan, NJ Medicaid, NJ Qualcare, Oscar Health Plan of PA, Oxford Health Plan, PA Health and Wellness (Centene) Medicare, PA Medicaid, PA Medicare, Provider Partners Health Plan, Rail Road Medicare / Palmetto GBA, Tricare, United Healthcare, UnitedHealthcare Community Plan, US Family Health Plan, Veterans Choice Program
Degrees
Medical Doctor
Admitting Hospitals
Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Pennsylvania Hospital
Office Name
Penn Neuroscience Center - Neurology
Services
alzheimer's testing, lumbar puncture, neurocognitive testing, neuropsychological assessment
Consumer Feedback
Add a Review
There are no recent reviews. Be the first!
©2024 Wellness®.com is a registered trademark of Wellness.com, Inc. 