Will Menopause Be A Thing Of The Past?

Italy is known for it's food and fashion but who would have guessed they'd also have the jump on helping women potentially eliminate menopause and it's associate symptoms using a common over-the-counter supplement - melatonin.

This is great news for all women, and a huge relief to those trying to decide which side effects to gamble on as a result of only knowing about traditional prescription drug therapies.

A six month study conducted by the Menopause Center at the Madonna Del Grazie Health Institute in Rome Italy, identified a clear relationship between nocturnal melatonin production, a hormone that makes us sleepy, and menopause.

Female subjects between the ages of 42 and 62 were given either a melatonin supplement or a placebo each night for six months. The subjects were either in the stages of perimenopause and experiencing missed menstrual cycles or post menopause and their menstrual cycles had ceased entirely.

Over the course of the six-month study an amazing thing occurred. The subjects who received the daily melatonin supplement resumed menstrual cyclicity. Yes even the women who were post menopausal regained their menstrual cycles.

Symptoms typically associated with menopause such as depression, sleep disorders, hot flushes, fatigue, difficulty concentrating, appetite disorders and tremors related to anxiety and depression were remarkably reversed or significantly improved.

Natural hormone levels were restored to youthful levels and the women receiving the melatonin became fertile again.

These results are nothing short of remarkable. While this is just a single study and should be viewed with that in mind, the potential ramifications are profound. If in fact the chicken-and-egg relationship between the onset of menopause and melatonin are the opposite as previously thought - that it is the reduction in melatonin that heralds the onset of menopause and not the reverse - then by simply supplementing with melatonin may completely reverse menopause. At least that is what the results of this study are pointing to.

This would most likely eliminate the need for hormone replacement therapy entirely as a transitional step to menopause since women would continue to produce youthful levels of hormones on their own. It would also greatly impact several segments of the pharmaceutical industry - anti-depressants, anti-anxiety and non-hormonal osteoporosis drugs that are now being hawked by celebrities like Sally Fields.

Imagine a world where women no longer have to fear fragile bones, or that their careers will be interrupted by the lack of energy or mental clarity suffered during menopause. How about mothers regularly giving birth at 75? Perhaps this will be a reality in the near future. We'll just have to wait and see.

While this is a single study and should be viewed as such, it will be interesting to see how physicians handle this news. This study was published in December of 2005. Will it be repressed or discounted? Remember, melatonin is an over-the-counter sleep aid and doesn't require a prescription. The pharmaceutical industry wont profit from this potentially wonderful discovery. That is unless they address it as they did the cholesterol-lowering effects of the common B vitamin - Niacin. They created an extended release version of an already perfect over-the-counter supplement called NiaSpan so that physicians would have something to prescribe. Most physicians are reluctant to recommend over-the-counter supplements citing purity is not guaranteed.

You'll have to educate yourself about your options when addressing menopause. Melatonin may prove to be a valuable aid for some women and may be worth examining for those of you beginning to see the symptoms of menopause.


* NiaSPan is a Registered Trademark of the KOS Pharmaceutical Company
4/17/2008 2:43:14 PM
SuperHumanRadio
Written by SuperHumanRadio
Hello, my name is Carl Lanore and I host the Super Human Radio show. Super Human Radio is dedicated to all aspects of fitness, health and anti aging. The show airs in a variety of US markets on terrestrial radio stations and I also get an International audience via the Podcast. I interview experts guest, authors, sci...
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Comments
Hi,
What is the optimal time to take the melatonin? 30 minutes before going to bed? Thank you.
Posted by Alina
Did the women who regained their menstrual cycles in the melatonin study regain fertlity and ovulate as well? Did this occur during the 6 month study and did the postmenopausal women (1-2 years) also regain fertlity? I have started taking melatonin as from 1 June 2011 as per your article with a view to regaining menstrual cycles and fertility. How long did it take into the study before menstrual cycles resumed? I would appreciate your input as fully as possible sothat I may have a guideline.
Posted by chilli
Can you please advise how long it took for the woman in the study who took melatonin for 6 months, before they resumed menstrual cycles particularly those who were postmenopausal for 1-2 years? Did the women regain their fertility and ovulate?
Posted by chilli
Maureen Kennedy Salaman (who wrote the book 'All Your health Questions Answered and was the host of 'Making Healthy Choices') said light interfered with the production of melatonin and that it should be taken after the lights are turned off, just before going to sleep. She also said that if you get up and turn on a light it nullifies the melatonin and it should be taken again. Do you know anything about this? Also, is sub lingual the preferable form or does it matter?
Posted by estel
of the women that were taking melatonin at 8pm to reverse menopause, how soon after were they going to bed? I work quite late into the night and so would like to know what the equivalent best time to take the tablet would be for me. Is it three-four hours before going to bed? I have just gone into menopause (missed two periods. I will keep you updated on the success I have with it.
Posted by ellejay999
Linda08 do you have any published documents that also show this? I've never heard this one before. I do know that very high levels of melatonin supplementation (above 25 Mgs) have been shown to interfere with sex hormone production. In fact one study showed that high levels of melatonin might be useful as a male contraceptive. I believe however this has more to do with a change in the timing of the pulse of sex steroid production rather than a true suppression. This has been evidenced in a couple studies that show the timing of the dose of melatonin alters the diurnal cycle of estrogen production. Here we see that the "when" of production is effected and not necessarily the "how much". Current anti-aging related interventive HRT generally include melatonin along with estrogen so I have to think that this is a misconception.
Posted by SuperHumanRadio
I read somewhere that taking melatonin along with hormone replacement therapy actually interferes and causes estrogen decline. So does that mean you have to choose one or the other?
Posted by Linda08
ewilson I have done a few years of research on melatonin and both interviewed for my show and spoken to over that same period Dr. Russell Reiter known to his colleagues as the godfather of melatonin. He has personally been involved in over 700 studies over 30+ years on the pineal gland and its major hormone - melatonin and I can say with a great degree of confidence that this is no true. What may occur however is a change in the heartbeat from taking too high a dose of melatonin. The reason for this is that melatonin acts on the seleno-enzyme cascade that produces deiodinase (<url removed> which gives thyroid hormone T3 is metabolic actions. This is evidenced by the profound protective action melatonin has on heart and liver tissue in hyperthyroid individuals. I've learned that the in-tissue landscape varies by organ and T3 has a profound effect on hearbeat. On that note I also believe that the standard 3MG OTC dose is too high a dose and that 1Mg or under is more suitable for most people. Humans produce the highest amount of melatonin prepubertal and the drop heralds puberty. This is why young children who have disrupted sleep patterns tend to experience precocious puberty. Melatonin is also the strongest anti-oxidant known to science. It also crosses the blood-brain-barrier with no challenge. Its a great supplement, but like all good things, in proper moderation. Carl
Posted by SuperHumanRadio
I think melatonin is awesome, but I heard that taking it regularly can cause heart problems.
Posted by ewilson
BethRosenshein I received your email and will be in touch to have you on the show. Thanks Carl
Posted by SuperHumanRadio
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