Peyote

safety

Allergies

Avoid in individuals with a known allergy or hypersensitivity to peyote, mescaline, or members of the family Cactaceae.

Side Effects and Warnings

There is limited available evidence describing the adverse effects of peyote. Due to the hallucinogenic activity of peyote, psychosis has been reported in case reports. Ritualistic use of peyote does not appear to cause long-term cognitive deficits, although more study is needed to clarify these findings.
Use cautiously in patients with mental disorders, as peyote may induce psychotic episodes.
Use cautiously in patients with high or low blood pressure, due to mescaline's potential to alter blood pressure.
Avoid in patients who are pregnant or breastfeeding due to the potential of fetal abnormalities.

Pregnancy and Breastfeeding

Peyote is not recommended in pregnant or breastfeeding women due to a lack of sufficient data in humans. Mescaline, a constituent of peyote, may cross the placenta, and has been linked to congenital malformations.

dosing

Adults (18 years and older):

There is no proven safe or effective dose for peyote in adults.

Children (younger than 18 years):

There is no proven safe or effective dose for peyote in children.

interactions

Interactions with Drugs

The biochemical alkaloids common in the peyote cactus are thought to be pharmacologically similar to the neuroamine-derived alkaloids found in the brain during alcohol intoxification. Caution is advised when taking peyote with alcohol.
Peyote extracts may regulate blood pressure, although the clinical significance of this is unknown. Caution is advised in patients taking agents that may also alter blood pressure.
Peyote may stimulate lymphocytes and leukocytes. Caution is advised when taking peyote with immunomodulators due to possible additive effects.
Chlorpromazine may affect the disposition of 8- 14 C-mescaline in fetal and maternal brain and liver. Caution is advised when taking peyote with phenothiazines.
Due to peyote's hallucinogenic effects, combined used with other psychoactives may cause additive effects. Caution is advised in patients with mental disorders.
Peyote may increase the amount of drowsiness caused by some drugs.

Interactions with Herbs and Dietary Supplements

In theory, due to peyote's hallucinogenic effects, combined used with other psychoactive herbs or supplements may cause additive effects. Caution is advised in patients with mental disorders.
Peyote extracts may regulate blood pressure, although the clinical significance of this is unknown. Caution is advised in patients taking herbs or supplements that may also alter blood pressure.
Peyote may stimulate lymphocytes and leukocytes. Caution is advised when taking peyote with immunomodulator herbs or supplements due to possible additive effects.
Peyote may increase the amount of drowsiness caused by some herbs or supplements.