Adrenal insufficiency (Addison's disease)
Addison's disease is a relatively common disorder to endocrinologists, but is rare and potentially fatal when presenting acutely. Treatment now involves replacement of glucocorticoids and mineralocorticoids with synthetic compounds, although historically patients took common salt and plant-based preparations, including licorice.
Limited study suggests that licorice may be beneficial in aplastic anemia, but results are inconclusive.
Apthous ulcers / canker sores
Some research suggests that licorice extracts, DGL, and the drug carbenoxolone, may provide benefits for treating cankers sores. However, studies have been small with flaws in their designs. The safety of DGL makes it an attractive therapy if it does speed healing of these sores, but it is not clear at this time whether there is truly any benefit.
Topical licorice extract gel has been shown to be effective in the treatment of atopic dermatitis in preliminary human study. Further research is needed to confirm these results.
Bleeding stomach ulcers caused by aspirin
Although there has been some study of DGL in this area, it is not clear what effects DGL has on gastrointestinal bleeding.
Further studies are needed prior to recommending for or against the use of glycyrrhizin in dental hygiene.
Familial Mediterranean fever (FMF)
Early study of a multi-ingredient preparation containing licorice, called Immunoguard™, suggests possible effects in managing FMF. Well-designed study of licorice alone is necessary before a recommendation can be made.
Early studies indicate that the herbal preparation STW 5, which contains licorice among many other herbal extracts, may help improve symptoms in patients with functional dyspepsia.
Herpes simplex virus
Laboratory studies have found that DGL may hinder the spread and infection of herpes simplex virus. Studies in humans have been small, but they suggest that topical application of carbenoxolone cream may improve healing and prevent recurrence.
High potassium levels resulting from abnormally low aldosterone levels
In theory, because of the known effects of licorice, there may be some benefits of licorice for high potassium levels caused by a condition called hypoaldosteronism. There is early evidence in humans in support of this use. However, research is preliminary and a qualified health care provider should supervise treatment.
Early studies suggest that glycyrrhizin may inhibit HIV replication in patients with AIDS. However, human reports are lacking. Additional study is needed to make a firm recommendation.
Shakuyaku-kanzo-to, an herbal medicine containing licorice, has been used for neuroleptic-induced hyperprolactinemia. However, additional studies are needed in this area.
Idiopathic thrombocytopenic purpura
Early study has suggested that recombinant roasted licorice decoction combined with low-dose glucocorticoids may be more effective than glucocorticoids alone in treating idiopathic thrombocytopenic purpura. This combination has also shown a lower adverse effect rate than glucocorticoids alone.
Many medical conditions are marked by inflammation. Because licorice can affect the metabolism of steroids, licorice is sometimes used to help decrease inflammation. Additional study is needed to make a firm recommendation.
Polycystic ovarian syndrome
Spironolactone is a synthetic steroid that is commonly used as a diuretic in women with polycystic ovary syndrome. Licorice has been used in combination with spironolactone to reduce side effects related to the diuretic activity of spironolactone.
Reducing body fat mass
Preliminary data shows that licorice may reduce body fat mass. Further research is needed to confirm these results.
Upper respiratory tract infections (common cold)
Historically, licorice has been used for its expectorant and anti-tussive effects. The herbal combination product, KanJang®, has been studied for the treatment of uncomplicated upper respiratory tract infections. Results are mixed, and additional study is needed.
The licorice extracts DGL and carbenoxolone have been proposed as possible therapies for viral hepatitis. Further research is needed before a recommendation can be made.
Peptic ulcer disease
Licorice extracts, DGL and carbenoxolone, have been studied for treating peptic ulcers. DGL (but not carbenoxolone) may offer some benefits. However, most studies are poorly designed and some results conflict. Therefore, it is unclear whether there is any benefit from licorice for this condition.