Acne

Conventional acne treatments are based around reducing oil production, speeding up skin cell turnover, fighting bacterial infection or all three. Acne treatments may take four to eight weeks for results.

Seeking treatment from a doctor for acne or acne-related symptoms may be necessary if embarrassment, mood changes, scaring, pain, or skin discoloration occurs.

Topical treatments: Topical products for acne may dry up the oil, kill bacteria and promote sloughing of dead skin cells. There are many different topical over-the-counter acne products available. The two most commonly used over-the-counter acne medications are benzoyl peroxide (such as Clean & Clear®, Persa-Gel®, or Oxy 10 Spot Treatment®) and salicylic acid (including Biore Blemish Bomb® or ClearasilStay Clear®, and Zone Control Clearstic®). Generally, these medications are useful for people with mild acne. They help to open up clogged pores and have some antibacterial activity. It can take several weeks to see an improvement in symptoms. If products containing salicylic acid and benzoyl peroxide don't work well, products with sulfur and/or resorcinol (such as Clearasil Adult Care®) may be used. While such products may be effective, they do have a noticeable color and odor.

Topical prescription medicines for acne include Tretinoin (Avita®, Retin-A®, Renova®) and adapalene (Differin®). These products are derived from vitamin A, and work by promoting cell turnover and preventing blockage of the hair follicle. A number of topical antibiotics also are available. They work by killing excess skin bacteria. Often, a combination of such products is required to achieve optimal results. Topical antibiotics may also be used, such as erythromycin and clindamycin.

Antibiotics: For moderate to severe acne, prescription oral or topical antibiotics may be needed to reduce bacteria and fight inflammation. Antibiotics may be used for months or years to control acne, and may be used alone or in combination with topical therapy. Antibiotics can cause side effects such as yeast infections and diarrhea. Antibiotics can also lessen the effectiveness of birth control pills by killing beneficial bacteria in the gastrointestinal tract that is responsible for hormone metabolism.

Tetracycline: Tetracycline is the most widely prescribed antibiotic for acne. The usual starting dose is 500mg twice a day continued until a significant decrease in acne lesions is seen. The dose can then be decreased to 250mg twice a day or discontinued. Tetracycline antibiotics must be taken on an empty stomach to be the most effective. Tetracycline should not be given to pregnant women or children under 9 years of age as tooth discoloration in children is common. Other tetraclyclines include minocycline (Minocin®, 50-100mg twice daily, especially useful for pustular type acne) and doxycycline (Vibramycin®, 50-100mg twice daily, may cause sun sensitivity).

Erythromycin: Erythromycin may also be used. It has anti-inflammatory properties that help reduce redness in lesions, in addition to killing bacteria. And it can and should be taken with food. The dosage of erythromycin varies with the type used, but it is typically prescribed as 250-500mg twice a day. It can cause stomach upset and nausea, but can be used in pregnant women.

Clindamycin: Clindamycin (Cleocin®) is very useful as an oral antibiotic for acne, but it is most widely prescribed as a topical antibiotic. The starting dose is 75-150mg twice a day. The major side effect of clindamycin therapy is serious intestinal infection called pseudomembranous colitis caused by the bacteria, Clostridium difficile.

Isotretinoin: Isotretinoin (Accutane®) may be used for scarring cystic acne or acne that doesn't respond to other treatments and is reserved for the most severe forms of acne. Although this therapy is very effective, individuals taking it need close monitoring by a doctor because of the possibility of severe side effects. Isotretinoin is associated with severe birth defects, so it cannot be taken by pregnant women or women who may become pregnant during the course of treatment or within several weeks of stopping treatment. Severe mental disorders including depression and suicide may also occur. Other serious side effects associated with the use of Accutane® include heart, brain, bone/muscle, gastrointestinal, cholesterol, hearing, vision, and liver problems. Severe allergic reactions have also been reported. Pharmacists must also hand out a detailed warning brochure from the U.S. Food and Drug Administration (FDA), called a Medguide, to all patients prescribed Accutane®.

Oral contraceptives: Oral contraceptives, including a combination of norgestimate and ethinyl estradiol (Ortho-Cyclen®, Ortho Tri-Cyclen®), have been reported to improve acne in women.

Cosmetic surgery: Cosmetic surgery may be used to diminish scars left by acne. Procedures include peeling away damaged skin with chemicals or by freezing it, dermabrasion, intense light therapy and laser resurfacing.

Strong scientific evidence :

Vitamin A: Derivatives of vitamin A, retinoids, are used to treat skin disorders such as acne. Vitamin A supplements should not be used simultaneously with prescription medications, especially Accutane®, due to a risk of increased toxicity.

Good scientific evidence :

Zinc: Several studies identify a positive correlation between serum zinc levels and severity of acne, however others did not, and it remains to be determined to which degree internal zinc levels may correlate with the severity of acne. Based on high quality studies, topical or oral use of zinc seems to be a safe and effective treatment for acne vulgaris.

Unclear or conflicting scientific evidence :

Guggul: Guggul (Commiphora mukul), an herbal supplement commonly used in India, has been found to possess anti-inflammatory properties and has been suggested as an oral therapy for acne. Preliminary data from small, methodologically weak human studies suggest possible short-term improvements in the number of acne lesions. Caution is advised when taking guggul supplements as adverse effects including drug interactions are possible. Guggul is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Tea tree oil: Topical application of tea tree (Melaleuca alternifolia) oil may be beneficial in acne. The tea tree is found in Australia and its oil is used for antibacterial effects, including positive studies on preventing and healing acne outbreaks. Tea tree oil is applied (diluted) onto areas with acne, three times daily.

Traditional or theoretical uses lacking sufficient evidence :

Aromatherapy: The use of essential oils may decrease the symptoms of acne. Essential oils are antibacterial and may kill the bacteria associated with acne. Apply diluted oils on a cotton ball to face as needed. Lavender essential oil may also be used topically to reduce scarring. Note: Essential oils are not to be consumed orally, as internal consumption can cause serious side effects.

Boswellia: Boswellia (Boswellia serrata) is an anti-inflammatory herb that has traditionally been used in acne therapy. Caution is advised when taking boswellia supplements as adverse effects including drug interactions are possible. Boswellia is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Burdock: Burdock root (Arctium lappa) is traditionally used for a wide range of conditions including acne. Although no scientific evidence exists for the use of burdock for acne, traditional uses support burdock's benefits in acne. Caution is advised when taking burdock supplements as numerous adverse effects including drug interactions are possible. Burdock is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Calendula: Calendula (Calendula officinalis), also known as pot marigold, is traditionally used for a wide range of conditions including acne. Although no scientific evidence exists for the use of calendula for acne, traditional uses support calendula's benefits in acne. Caution is advised when taking calendula supplements as numerous adverse effects including drug interactions are possible. Calendula is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Cat's claw: Cat's claw (Uncaria tomentosa) is a vine found in South America used traditionally for a wide range of conditions including acne. Although no scientific evidence exists for the use of cat's claw for acne, traditional uses support cat's claw's benefits in acne. Caution is advised when taking cat's claw supplements as numerous adverse effects including drug interactions are possible. Cat's claw is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Chasteberry: Chasteberry or vitex (Vitex agnus-castus) is reported to have hormonal effects similar to progesterone in the body, and one of the causes of acne may be hormonally related. Vitex was reported in one human study to improve the symptoms of acne. Caution is advised when taking vitex supplements as numerous adverse effects including drug interactions are possible. Vitex is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Danshen: Danshen (Salvia miltiorrhiza) is widely used in traditional Chinese medicine (TCM), often in combination with other herbs. Although no scientific evidence exists for the use of danshen for acne, traditional uses support danshen's benefits in acne. Caution is advised when taking danshen supplements as numerous adverse effects including drug interactions are possible. Danshen is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Echinacea: Echinacea is used traditionally for a wide range of conditions including acne. Although no scientific evidence exists for the use of echinacea for acne, traditional uses support echinacea's benefits in acne. Caution is advised when taking echinacea supplements as numerous adverse effects including drug interactions are possible. Echinacea is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Milk thistle: Milk thistle (Silybum marianum) is used to detoxify the liver and as an antioxidant. Detoxification therapies can be helpful in decreasing acne outbreaks and symptoms. Caution is advised when taking milk thistle supplements as adverse effects including drug interactions are possible. Milk thistle is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Moxibustion: Moxibustion is a Traditional Chinese Medicine technique that uses cupping and heat to stimulate circulation and break up congestion or stagnation of blood and chi. A study of 47 individuals found that moxibustion was effective in acne treatment.

Nicotinamide: Studies have reported that nicotinamide in doses of 750 milligrams, combined with zinc 25 milligrams, copper 1.5 milligrams, and folic acid 500 micrograms, is effective in treating acne vulgaris with or without antibiotics.

Omega: Omega-3 fatty acids, such as fish oils, help with inflammation and immunity associated with acne. Experts recommend choosing quality fish oil supplements, as heavy metals have been reported in some fish oil supplements. The label should say if the product has been tested for heavy metal contamination (such as lead and mercury).

Phototherapy: Studies have reported that visible light may successfully be used to treat acne, particularly intense blue light generated by purpose-built fluorescent lighting, dichroic bulbs, LEDs or lasers. Used twice weekly, this has been reported to reduce the number of acne lesions by about 64%.

Probiotics: If a patient is taking antibiotics for acne, probiotic supplements may be effective in reducing effects associated with antibiotic and antiviral therapies such as diarrhea or constipation. The gastrointestinal tract normally has bacteria such as Lactobacillus acidophilus (considered a probiotic)that help in balancing the immune system. Probiotics are generally safe in recommended dosages, but may cause mild diarrhea.

Saw palmetto: Saw palmetto (Serenoa repens) may help balance male hormonal levels and may be used in acne therapy. Although no scientific evidence exists for the use of saw palmetto for acne treatment or prevention, traditional uses support saw palmetto's benefits in acne. Caution is advised when taking saw palmetto supplements as numerous adverse effects including drug interactions are possible. Saw palmetto is not recommended during pregnancy or breastfeeding unless otherwise advised by a doctor.

Stress reduction: Stress has been associated with occurrence of acne. Meditation, exercise, music therapy, and massage have been reported to decrease stress.

Wash the face with mild soap and water several times daily to prevent pore clogging and oil buildup.

Avoid repeated exposure to an environment that promotes oil production and clogging of the pores.

Rubbing and friction from clothing, hair, and sporting equipment may also irritate acne-prone skin.

Try not to "pop" pimples or touch them, as infection may occur.

Avoid skin irritants such as cosmetics or shaving with an electric razor.

Nutritional changes along with the addition of supplements (vitamins, minerals and herbs) may be effective in preventing acne, improving immunity, decreasing stress, and in supporting general health.

Taking a multivitamin that contains the antioxidant vitamins A, C, and E, the B-complex vitamins, and trace minerals such as magnesium, zinc, and selenium can help protect the body from acne.

Although still controversial, consuming less dairy products such as milk and cheese, may decrease acne. It is thought that the hormones contained in milk may be a causative factor in developing acne. Drinking soy milk or organic milk that does not contain hormones may help decrease acne.

Try to avoid refined foods such as white breads, pastas, and sugar. The high glycemic index of these foods has been reported to increase acne outbreaks and symptoms.

Eat antioxidant containing foods, including fruits (such as berries, grapes, and tomatoes), and vegetables (such as peppers and carrots). Studies report that oxidation may be a causative factor in developing acne.

Seafood, which contains high levels of iodine, has been reported to increase the incidence of getting acne. Avoiding seafood may decrease the chances of developing acne.

Chocolate has been thought to cause acne for years, but scientists have found no link between chocolate consumption and acne outbreaks. However, overconsumption, especially of milk chocolate, may cause poor glycemic control which may increase the chances of acne outbreaks.