Pronunciation(myoo PEER oh sin)
U.S. Brand NamesBactroban®; Bactroban® Nasal; Centany™
SynonymsMupirocin Calcium; Pseudomonic Acid A
Generic AvailableYes: Topical ointment
Canadian Brand NamesBactroban®
UseIntranasal: Eradication of nasal colonization with MRSA in adult patients and healthcare workers
Topical treatment of impetigo due to Staphylococcus aureus, beta-hemolytic Streptococcus, and S. pyogenes
Use - Unlabeled/InvestigationalIntranasal: Surgical prophylaxis to prevent wound infections
Pregnancy Risk FactorB
Pregnancy ImplicationsThere are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed.
LactationExcretion in breast milk unknown/use caution
ContraindicationsHypersensitivity to mupirocin, polyethylene glycol, or any component of the formulation
Warnings/PrecautionsPotentially toxic amounts of polyethylene glycol contained in the vehicle may be absorbed percutaneously in patients with extensive burns or open wounds; prolonged use may result in over growth of nonsusceptible organisms; for external use only; not for treatment of pressure sores
Adverse ReactionsFrequency not defined. Central nervous system: Dizziness, headache
Dermatologic: Pruritus, rash, erythema, dry skin, cellulitis, dermatitis
Gastrointestinal: Nausea, taste perversion
Local: Burning, stinging, tenderness, edema, pain
Respiratory: Rhinitis, upper respiratory tract infection, pharyngitis, cough
Drug InteractionsNo data reported
StabilityDo not mix with Aquaphor®, coal tar solution, or salicylic acid
CompatibilityDo not mix with Aquaphor®, coal tar solution, or salicylic acid.
Mechanism of ActionBinds to bacterial isoleucyl transfer-RNA synthetase resulting in the inhibition of protein and RNA synthesis
Pharmacodynamics/KineticsAbsorption: Topical: Penetrates outer layers of skin; systemic absorption minimal through intact skin
Protein binding: 95%
Metabolism: Skin: 3% to monic acid
Half-life elimination: 17-36 minutes
Excretion: Urine
DosageChildren  12 years and Adults: Intranasal: Approximately one-half of the ointment from the single-use tube should be applied into one nostril and the other half into the other nostril twice daily for 5 days
Children 3 months and Adults: Topical: Apply small amount to affected area 2-5 times/day for 5-14 days
Patient EducationFor external use only. Wash hands before and after application. Apply thin film over affected areas exactly as directed. Avoid getting in eyes. Report rash, persistent burning, stinging, swelling, itching, or pain. Contact prescriber if no improvement is seen in 3-5 days. Breast-feeding precaution: Consult prescriber if breast-feeding.
Nursing ImplicationsNot for treatment of pressure sores in elderly patients; contains polyethylene glycol vehicle
Additional InformationNot for treatment of pressure sores; contains polyethylene glycol vehicle.
Dental Health: Effects on Dental TreatmentNo significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic PrecautionsNo information available to require special precautions
Mental Health: Effects on Mental StatusNone reported
Mental Health: Effects on Psychiatric TreatmentNone reported
Dosage FormsCream, topical, as calcium (Bactroban®): 2% (15 g, 30 g) [contains benzyl alcohol]
Ointment, intranasal, topical, as calcium (Bactroban® Nasal): 2% (1 g) [single-use tube]
Ointment, topical: 2% (22 g)
Bactroban®: 2% (22 g)
Centany™: 2% (15 g, 30 g)
ReferencesBlumer JL, Lemon E, O'Horo J, et al, "Changing Therapy for Skin and Soft Tissue Infections in Children: Have We Come Full Circle?"Pediatr Infect Dis J, 1987, 6(1):117-22.
Britton JW, Fajardo JE, and Krafte-Jacobs B, "Comparison of Mupirocin and Erythromycin in the Treatment of Impetigo,"J Pediatr, 1990, 117(5):827-9.
Goldfarb J, Crenshaw D, O'Horo J, et al, "Randomized Clinical Trial of Topical Mupirocin Versus Oral Erythromycin for Impetigo,"Antimicrob Agents Chemother, 1988, 32(12):1780-3.
Perl TM, Cullen JJ, Wenzel RP, et al, "Intranasal Mupirocin to Prevent Postoperative Staphylococcus aureus Infections,"N Engl J Med, 2002, 346(24):1871-7.
International Brand NamesBactoderm® (ID, IL); Bactroban® (AR, AT, AU, BE, BR, CA, CH, CL, CO, CR, CZ, DK, DO, ES, FI, FR, GB, GT, HK, HN, HU, ID, IE, IL, IN, IT, KW, LU, MX, NL, NZ, PA, PL, PT, RO, RU, SE, SG, SV, TH, TR, YU, ZA); Bactroban Nasal® (CH, FI, GB, IE, IL, SE); Betrion® (HR, SI); Infectopyoderm® (DE); Mupiderm® (FR); Mupirocina® (BR); Mupirocin-Teva® (IL); Mupirox® (AR, PL); Muporin® (TH); Plasimine® (ES); Seladerm® (EC); Turixin® (DE); Underan® (CL)
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