Avoid in individuals with a known allergy or hypersensitivity to strawberry (Fragaria spp.) or its constituents. Hypersensitivity to strawberry is fairly common, especially among children, although there are only a few cases of patients with adverse reactions to strawberry listed in the currently available literature, compared to other Rosaceae fruit. There is some evidence that some proteins in strawberries are homologues for birch pollen and stone and pome fruit allergens, which may explain the prevalence of strawberry sensitivity. There also seems to be a connection between acetylsalicylic acid intolerance and strawberry sensitivity.

Strawberries are likely safe when used in food amounts in healthy patients. Strawberry extract, or very large amounts of strawberries may be unsafe if consumed by pregnant patients, due to insufficient available evidence. In sensitive subjects, strawberry has caused contact urticaria (hives) and pruritic dermatoses (eczema and neurodermite). Strawberries, especially fresh ones, may be contaminated with bacteria, pesticides, or fungi, and should be thoroughly washed before consuming.

Use cautiously in patients with hematological (blood) disorders or in patients taking anticoagulants or antiplatelet agents (blood thinners).

Use cautiously in patients with iron-absorption disorders.

Based on traditional use as a food, the food amounts seem safe. Larger amounts and strawberry extract are not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

There is no proven effective dose for strawberry.

There is no proven effective dose for strawberry in children.

Individual compounds in strawberries have demonstrated anticancer activity in several different studies. Caution is advised when taking strawberry with anticancer agents.

Strawberry may have blood-thinning properties. Caution is advised in patients with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.

Strawberry may have antioxidant, anti-inflammatory, and antibacterial properties. Caution is advised when taking strawberry with agents with similar effects.

Although not well studied in humans, strawberry extract may interfere with gastrointestinal absorption of drugs taken by mouth. Strawberry (Fragaria spp.) may have a mild to moderate enhancing effect on iron absorption.

Based on tests performed in allergic patients, there may be a connection between acetylsalicylic acid intolerance and strawberry sensitivity.

Individual compounds in strawberries have demonstrated anticancer activity in several different studies. Caution is advised when taking strawberry with herbs and supplements with anticancer effects.

Strawberry may have blood-thinning properties. Caution is advised in patients with bleeding disorders or taking herbs or supplements that may increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto.

Strawberry may have antioxidant, anti-inflammatory, and antibacterial properties. Caution is advised when taking strawberry with herbs and supplements with these properties.

Although not well studied in humans, strawberry extract may interfere with gastrointestinal absorption of herbs and supplements taken by mouth. Strawberry (Fragaria spp.) may have a mild to moderate enhancing effect on iron absorption.

Based on tests performed in allergic patients, there may be a connection between acetylsalicylic acid intolerance and strawberry sensitivity.